Days of miracle and wonder
My youngest son, James, is an undergraduate in his third year at the University of Sydney. His world is more like yours, dear reader, than mine. It differs from mine …
The future of Indigenous health in Australia
In 1866 the first Indigenous Canadian doctor completed her training and in 1899 the first Maori doctor graduated from medical school in the United States. Professor Helen Milroy, a founding …
Aripiprazole as first-line treatment of late-onset schizophrenia – a case report and literature review
Introduction: Guidelines for the first-line treatment for late-onset schizophrenia (LOS) in the elderly patient have not been established. The current recommended treatment of schizophrenia in younger age groups has been …
Resistance to epidermal growth factor receptor inhibitors in non-small cell lung cancer and strategies to overcome it
The War on Cancer has been a particularly long, drawn-out one ever since the National Cancer Act was put into legislation by then U.S. President Richard Nixon. While we attempt …
Glibenclamide therapy as tertiary prevention of melioidosis for Type 2 diabetics.
Background: Melioidosis is a relatively high-incidence, high-mortality tropical infectious disease caused by Burkholderia pseudomallei. To date, the few prevention and management strategies in practice have failed to reduce mortality from …
About Helen Caldicott’s guest article
As a university academic whose professional interests include the chemistry of serious reactor accidents I disagree with many of the statements made by Helen Caldicott in her recent article “The …
Insights into the application of evolutionary and ecological concepts to cancer treatment via modelling approaches
Therapeutic resistance has been shown to result in poorer clinical outcomes in cancer treatment. It has been proposed that evolutionary adaptations of cancer cells to therapy result in the development …
A review of early intervention in youth psychosis
Early intervention in youth psychosis has been a topic of contentious discussion. In particular, there is a lack of consensus regarding how early to treat patients with a psychotic disorder. …
The α-5 subunit-containing GABA-A receptor: a target for the treatment of cognitive defects
Amnesic effects of benzodiazepines are in part the result of the activity of α5-subunit containing GABAA receptors (GABRA5). Negative modulators at this receptor could improve cognition. In order to explore …
Psychopathy: A disorder or an evolutionary strategy?
I am writing to discuss an interesting construct in psychiatry often referred to as ‘psychopathy’. In psychiatry there is often lively debate about how we should classify and define psychopathology, …