Treatment of persistent diabetic macular oedema – intravitreal bevacizumab versus laser photocoagulation: A critical appraisal of BOLT Study for an evidence based medicine clinical practice guideline
By Pavani Kurra | Volume 3, Issue 2 2012
Laser photocoagulation has remained the standard of treatment for diabetic macular oedema (DME) for the past three decades. However, it has been shown to be unbeneficial in chronic diffuse DME. Intravitreal bevacizumab (ivB) has been proposed as an alternate and effective treatment of DME. This review evaluates the evidence behind comparing bevacizumab to laser photocoagulation [...]
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Seasonal influenza vaccination in antenatal women: Views of health care workers and barriers in the delivery of the vaccine
By Surabhi Khosla | Volume 3, Issue 2 2012
Background: Pregnant women are at an increased risk of developing influenza. The National Health and Medical Research Council recommends seasonal influenza vaccination for all pregnant women who will be in their second or third trimester during the influenza season. The aim of this review is to explore the views of health care workers regarding seasonal [...]
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Spontaneous regression of cancer: A therapeutic role for pyrogenic infections?
By Kok-Ho Ho | Volume 3, Issue 2 2012
Spontaneous regression of cancer is a phenomenon that is not well understood. While the mechanisms are unclear, it has been hypothesised that infections, fever and cancer are linked. Studies have shown that infections and fever may be involved in tumour regression and are associated with improved clinical outcomes. This article will examine the history, evidence [...]
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The therapeutic potentials of cannabis in the treatment of neuropathic pain and issues surrounding its dependence
By Stephanie Sargent | Volume 3, Issue 2 2012
Cannabis is a promising therapeutic agent, which may be particularly beneficial in providing adequate analgesia to patients with neuropathic pain intractable to typical pharmacotherapy. Cannabinoids are the lipid-soluble compounds that mediate the analgesic effects associated with cannabis by interacting with the endogenous cannabinoid receptors CB1 and CB2, which are distributed along neurons associated with pain [...]
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A biological explanation for depression: The role of interleukin-6 in the aetiology and pathogenesis of depression and its clinical implications
By Stephy Zhang | Volume 3, Issue 2 2012
Depression is one of the most common health problems addressed by general practitioners in Australia. It is well known that biological, psychosocial and environmental factors play a role in the aetiology of depression. Research into the possible biological mechanisms of depression has identified interleukin-6 (IL-6) as a potential biological correlate of depressive behaviour, with proposed [...]
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Where to from here for Australian childhood obesity?
By Jasmine Antoine | Volume 3, Issue 2 2012
Aim: At least one in twenty Australian school children are obese. [1] The causes and consequences of childhood obesity are well documented. This article examines the current literature on obesity management in school-aged, Australian children. Methods: A systematic review was undertaken to examine the efficacy of weight management strategies of obese Australian school-aged children. Search [...]
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The future of personalised cancer therapy, today
By May Wong | Volume 3, Issue 1 2012
With the human genome sequenced a decade ago and the concurrent development of genomics, pharmacogenetics and proteomics, the field of personalised cancer treatment appears to be a maturing reality. It is recognised that the days of ‘one-sizefi ts-all’ and ‘trial and error’ cancer treatment are numbered, and such conventional approaches will be refined. The rationale [...]
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Is Chlamydia trachomatis a cofactor for cervical cancer?
By Surabhi Khosla | Volume 3, Issue 1 2012
Introduction The most recent epidemiological publication on the worldwide burden of cervical cancer has reported that cervical cancer (0.53 million cases) was the third most common female cancer reported in 2008 after breast (1.38 million cases) and colorectal cancer (0.57 million cases). [1] Cervical cancer is the leading source of cancer-related death among women in [...]
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Ear disease in Indigenous Australians: A literature review
By Sarah Hill | Volume 3, Issue 1 2012
Introduction The Australian Indigenous versus non-Indigenous mortality gap is worse in Australia than in any other Organisation for Economic Coopera tion and Development nation with disadvantaged Indigenous populations, including Canada, New Zealand, and the USA. [1] This gap reached a stark peak of seventeen years in 1996-2001. [2] Otitis media affects 80% of Australian children [...]
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Suxamethonium versus rocuronium in rapid sequence induction: Dispelling the common myths
By Sean Davies | Volume 3, Issue 1 2012
Rapid sequence induction (RSI) is a technique used to facilitate endotracheal intubation in patients at high risk of aspiration and for those who require rapid securing of the airway. In Australia, RSI protocols in emergency departments usually dictate a predetermined dose of an induction agent and a neuromuscular blocker given in rapid succession. Suxamethonium, also [...]
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