Pathogenesis of severe allergic asthma and the therapeutic use of anti- immunoglobulin E antibody

By Rukaiya Malik | Volume 6, Issue 1 2015

Allergic asthma involves type 1 hypersensitivity, which is driven by immunoglobulin E (IgE) dependent immunological mechanisms. Severe asthma is associated with chronically persisting inflammation and is often relatively unresponsive to conventional treatment with corticosteroids. This review article summarises the best treatment for severe persistent asthmatics based on current understanding of its pathogenesis. The... 

Download PDF | Read the full article online

Stroke prevention in non-valvular atrial fibrillation: advances in medical therapy

By Dr. Karishma Zobair | Volume 6, Issue 1 2015

Introduction: The aim of this article is to review the literature and evaluate the evidence of the different medical treatments for stroke prevention in non-valvular atrial fibrillation. Methods: A literature search using MEDLINE plus OvidSP, PubMed, CINAHL and the New England Journal of Medicine databases was performed with the search terms stroke prevention, atrial fibrillation, […]  Read More →

Download PDF | Read the full article online

Chronic obstructive pulmonary disease: extrapulmonary manifestations, pulmonary rehabilitation programs and the role of nutritional biomarkers on patient outcomes

By Melissa McDonald | Volume 6, Issue 1 2015

Until recently, chronic obstructive pulmonary disease (COPD) received little research attention, as it was perceived as a self- inflicted condition that was difficult to treat. As COPD now affects one in seven Australians over 40 and is a leading cause of disease burden and death, research into this condition has intensified. Traditionally, research focused on […]  Read More →

Download PDF | Read the full article online

Does increased geographical distance to a radiation therapy facility act as a barrier to seeking treatment?

By Divya Kiran Sharma | Volume 6, Issue 1 2015

Introduction: Radiation Therapy (RT) is a common treatment modality for cancer management. Due to specific licensing and expertise  requirements,  RT  tends  to  be  centralised  in  larger urban  centres  resulting  in  restricted  geographical  access  for many. Several studies conducted have examined the relationship between distance to treatment and utilisation of RT, however there remains a gap […]  Read More →

Download PDF | Read the full article online

Complementary medicine and hypertension: garlic and its implications for patient centred care and clinical practice

By Angus S Lane | Volume 6, Issue 1 2015

This review aims to explore the impact that patient attitudes, values and beliefs have on healing and the relevant implications these have for clinical practice and patient centred care. Using a Cochrane review as a platform, garlic as a complementary medicine was evaluated based on current societal trends and pertinent clinical practice points. The study […]  Read More →

Download PDF | Read the full article online

HIV/AIDS: let’s see how far we’ve come

By Lauren Fowler | Volume 6, Issue 1 2015

Now  more  than  ever,  HIV  positive  people  are  living  longer and healthier lives because of access to antiretroviral therapy. Healthcare organisations are working to ensure that HIV positive people all over the world have access to the medical care they need to stay healthy. In the last few years, research into vaccine development, genetics-based approaches […]  Read More →

Download PDF | Read the full article online

Insights into the mechanism of ‘chemobrain’: deriving a multi-factorial model of pathogenesis

By Kok-Ho Ho | Volume 6, Issue 1 2015

Chemotherapy-related  cognitive  impairment,  commonly called ‘chemobrain’, is a potentially debilitating condition that is slowly being  recognised.  It  encompasses  a  wide  range  of  cognitive domains  and  can  persist  up  to  years  after  the  cessation  of chemotherapy.  What  initially  appears  to  be  a  straightforward example of neurotoxicity may be a complex interplay... 

Download PDF | Read the full article online

Glass micro-particulate contamination of intravenous drugs – should we be using filter needles?

By Lewis Fry | Volume 6, Issue 1 2015

The universal use of filter needles in the aspiration of all medications from glass ampoules for intravenous administration has been recommended due to safety concerns surrounding possible inadvertent injection of glass micro-particulate created from snapping open ampoules. Implementing this would involve significant costs. This article aims to review the relevant literature to evaluate whether sufficient […]  Read More →

Download PDF | Read the full article online

Venous thromboembolism: a review for medical students and junior doctors

By Dr. Richard E Pow | Volume 6, Issue 1 2015

Venous  thromboembolism,  comprising  deep  vein  thrombosis and pulmonary embolism, is a common disease process that accounts  for  significant  morbidity  and  mortality  in  Australia. As  the  clinical  features  of  venous  thromboembolism  can  be non-specific, clinicians  need  to  have  a  high  index  of  suspicion for   venous   thromboembolism.   Diagnosis   primarily  ... 

Download PDF | Read the full article online

Bispectral analysis for intra-operative monitoring of the neurologically impaired: a literature review

By Jacob Gipson | Volume 6, Issue 1 2015

Introduction: The bispectral index (BIS) is a technology which uses a modified electroencephalogram (EEG) to predict the likelihood that an anaesthetised patient has awareness of their surroundings. This method of monitoring was developed by analysing the EEGs of approximately 1000 patients with normal neurological function. It therefore has questionable applicability to those with neurological disability […]  Read More →

Download PDF | Read the full article online