Cricoid pressure in contemporary anaesthesia

By Niranjan J Sathianathen | Volume 7, Issue 1 2016

Aim: To evaluate the role of cricoid pressure in modern day anaesthetics. Methods: A literature review was conducted using the following databases: The Cochrane Database of Systematic Reviews, PubMed, Scopus, Ovid MEDLINE and EMBASE. Articles were found using following terms: cricoid pressure, aspiration, laryngoscopy, airway obstruction, anaesthesia, anaesthesiology, airway management, Sellick’s and rapid sequence... 

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A review of current and novel treatment strategies for chronic plaque psoriasis

By Yiliang Zheng | Volume 7, Issue 1 2016

Psoriasis is a chronic, immune-mediated inflammatory dermatosis with many comorbidities, particularly psoriatic arthritis, metabolic syndrome, and depression. Psoriasis has a significant impact on quality of life, especially for those with severe disease. It is therefore important for the physician to evaluate patient preferences and choices when considering an optimal treatment approach and therapeutic regimen for […]  Read More →

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Strategies to overcome tamoxifen resistance in breast cancer

By Farzana Y Zaman | Volume 7, Issue 1 2016

The selective oestrogen receptor modulator (SERM), tamoxifen, is pivotal in treating oestrogen receptor positive (ER+) breast cancers—the most common subtype of breast cancer.  As the first targeted therapy for breast cancer, tamoxifen remains the gold standard of adjuvant endocrine therapy.  However, this important drug has its limitations: its efficacy is frequently hampered by the phenomenon […]  Read More →

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Is switching anticoagulant brands safe – Coumadin and Marevan?

By Fiona Chen, Ian Wang, Linda Graudins, Ingrid Hopper | Volume 7, Issue 1 2016

Aim: Warfarin is the most frequently prescribed antithrombotic agent, available in Australia as brands Coumadin and Marevan. Although both are manufactured by Aspen Pharmaceuticals, there are differences in formulation. The product information states they cannot be used interchangeably. Two incident reports of warfarin brand interchange in our hospital prompted a literature review. We aimed to […]  Read More →

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Systematic review article: Evidence for interventions to reduce the incidence of abusive infant head trauma

By Hannah G Royster | Volume 7, Issue 1 2016

Background: Abusive Infant Head Trauma (AIHT) is preventable, but there are few reviews of interventions to prevent AIHT.  In the Australian health system context, only one review of AIHT was found. Its primary focus was to raise awareness of AIHT, detailing AIHT incidence and outcomes, but only briefly touching on prevention. [1] This literature review […]  Read More →

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The impaired student: Substance abuse in medical students

By Lewis Fry | Volume 6, Issue 2 2015

Substance use disorder has been a significant issue within the medical profession throughout history. It is recognised as an important issue of concern, particularly due to its associated mortality, morbidity and social consequences. Although a substantial body of literature addresses this issue amongst doctors, there is little discussion focusing on medical students. This review summarises […]  Read More →

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Is cellular senescence a viable strategy and endpoint for oncological control?

By Kok-Ho Ho | Volume 6, Issue 2 2015

Apoptosis is considered the main form of cell death in cancer cells undergoing cytotoxic treatments such as chemotherapy and radiotherapy. However, disappointing treatment response rates in some cancers have prompted a rethink regarding oncological control methods. Cellular senescence has emerged as a possible tumour suppression strategy that may effectively control cancer cells when apoptosis fails. […]  Read More →

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Perioperative pain management – should we pre-empt or prevent pain?

By Dr. Lukman Anderson | Volume 6, Issue 2 2015

Central sensitisation is the process whereby nociceptive inputs trigger increased excitability and synaptic efficiency of central nociceptive pathways, and is a key process in the development of chronic postoperative pain. Pre-emptive analgesia, whereby analgesia is given prior to surgical incision, has previously been advocated as a method of decreasing the process of central sensitisation and […]  Read More →

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Perioperative glycaemic control in diabetic surgical patients – review

By Andrew Zhang | Volume 6, Issue 2 2015

Glycaemic control around the time of surgery is a critical part of surgical care in diabetic patients. There is a high prevalence of diabetes mellitus worldwide, and the disease is becoming more common in both medical and surgical patients. Even in patients without diabetes, surgery disrupts usual diabetic management and glucose homeostasis, often resulting in […]  Read More →

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Risk factors for iatrogenic opioid dependence: An Australian perspective

By Hannah Hartman | Volume 6, Issue 2 2015

The prescription of opioids is increasing worldwide, including in Australia. Consequently, opioid dependence – one of several harms associated with chronic opioid therapy – is now a growing concern. However, the risk factors for iatrogenic opioid dependence are not well understood in an Australian context. The available Australian evidence for these risks are reviewed and […]  Read More →

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