Aripiprazole as first-line treatment of late-onset schizophrenia – a case report and literature review

By Tasciana Gordon | Volume 5, Issue 1 2015

Introduction: Guidelines for the first-line treatment for late-onset schizophrenia (LOS) in the elderly patient have not been established. The current recommended treatment of schizophrenia in younger age groups has been extrapolated to those in the older age groups. This report considers the effects of medication specific to this demographic. Case study: BB, a 73-year-old male, […]  Read More →

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Resistance to epidermal growth factor receptor inhibitors in non-small cell lung cancer and strategies to overcome it

By Bernard Chua | Volume 5, Issue 1 2015

The War on Cancer has been a particularly long, drawn-out one ever since the National Cancer Act was put into legislation by then U.S. President Richard Nixon. While we attempt to reveal the mechanisms that sustain the uncontrolled growth of cancer cells, the biology of cancer constantly changes and adapts to evade our treatment modalities. […]  Read More →

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Glibenclamide therapy as tertiary prevention of melioidosis for Type 2 diabetics.

By Raelene Aw-Yong | Volume 5, Issue 1 2015

Background: Melioidosis is a relatively high-incidence, high-mortality tropical infectious disease caused by Burkholderia pseudomallei. To date, the few prevention and management strategies in practice have failed to reduce mortality from septic shock in patients with severe melioidosis. Up to 60.9% of patients also have pre-existing type 2 diabetes mellitus (T2DM), the most significant risk factor […]  Read More →

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A review of early intervention in youth psychosis

By Dr. Helmut C Y Yu, Dr. Nimenka Ramanayake, Dr. Vivek Baskaran, Dr. Hannah Hsu, Dr. Jennifer Truong, Dr. Geoffrey Balean | Volume 5, Issue 1 2015

Early intervention in youth psychosis has been a topic of contentious discussion. In particular, there is a lack of consensus regarding how early to treat patients with a psychotic disorder. There has been a recent push to provide treatment early in the development of psychosis, specifically to patients in an ultra-high risk or prodromal stage. […]  Read More →

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The α-5 subunit-containing GABA-A receptor: a target for the treatment of cognitive defects

By Abhishta Pierre Bhandari | Volume 5, Issue 1 2015

Amnesic effects of benzodiazepines are in part the result of the activity of α5-subunit containing GABAA receptors (GABRA5). Negative modulators at this receptor could improve cognition. In order to explore this beneficial effect, this article reviews the evidence on the effects of GABRA5 negative modulators and searches potential uses for such drugs. A literature search […]  Read More →

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Factors that influence Australian medical graduates to become General Practitioners

By Karan Singh | Volume 4, Issue 2 2014

Aim: To determine the factors that influence Australian medical graduates to become general practitioners. Method: A literature review was conducted. Medline, PubMed and Cochrane Library were searched using the terms; “Australia”, “medical”, “graduates”, “interns”, “students”, “choice”, “specialty”, “general”, “practice”, “factors” and “influencing”. Results: The factors were... 

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Sugammadex – the solution to our relaxant problems?

By Henry Badgery | Volume 4, Issue 2 2014

Sugammadex is the first of a class of selective relaxant binding agents. It acts by binding with high affinity to steroidal non-depolarising neuromuscular blockade drugs terminating neuromuscular blockade (NMB) through 1:1 encapsulation. Reversal of NMB has traditionally been performed by acetylcholinesterase inhibitors however these drugs have their drawbacks and are therefore not ideal.  This review […]  Read More →

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Examining the pathological nature of Hepatitis C and current drug therapies used in an Australian general practice context

By Dimitra Aslanidis | Volume 4, Issue 2 2014

Aim: This review aims to examine the pathological nature of Hepatitis C and review current drug therapies relevant to Australian health practitioners. Methods: Terms hepatitis C, Australia, pathogenesis and current treatment were searched using MEDLINE and CHINAL databases to identify research articles and systematic reviews. Constraints were used when researching drug developments to include only […]  Read More →

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Is plasmapheresis the optimal treatment option for acute pancreatitis secondary to hypertriglyceridemia? A systematic review

By Mohammad Rehmanjan | Volume 4, Issue 2 2014

Background: Hypertriglyceridemia is an uncommon cause of acute pancreatitis, which is a life-threatening illness. Conventional management involves fasting, lipid-lowering medication, insulin and heparin. Plasmapheresis is an approach which is used occasionally to achieve rapid lowering of triglyceride levels in patients where conventional management is unsuccessful. It is currently unclear whether plasmapheresis improves... 

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A systematic review evaluating non-invasive techniques to diagnose genetic disorders in a human fetus and the ethical implications of their use

By Matthew Irwin | Volume 4, Issue 2 2014

Introduction: Genetic disorders are a significant cause of neonatal morbidity and mortality. [1] Diagnosing a genetic disorder currently involves invasive tissue sampling which carries an increased risk of miscarriage. The discovery of cell-free fetal DNA (cffDNA) in maternal plasma has enabled the development of non-invasive prenantal diagnostic tests (NIPD). [2,3] The scientific and ethical implications […]  Read More →

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