Intravenous Magnesium Therapy Treatment of Severe Asthma in Adults
This article systematically analyses the evidence behind the use of intravenous magnesium sulphate in adults with severe acute exacerbations of asthma.
Efficacy and Safety of Allergen Immunotherapy to Treat House Dust Mite Allergic Asthma in Children
Allergic asthma is a significant disease of childhood, of which, house dust mite is the most common trigger. There have been many investigations into the role of allergen immunotherapy in …
Paediatric simulation teaching for medical students: a review of current literature
The objective of this review article is to determine whether simulation-based education could enhance the teaching of paediatrics to Australian medical students. A literature search of PubMed and Embase was performed …
Management of burn wound pain in the hospital setting
In Australia, burns are common, accounting for around 5500 hospital injuries each year. The proper management of burn pain is crucial to the rehabilitation process and in reducing the chance of long …
A Review of Breath Metabolic Profiling for Non-invasive Testing in Inflammatory Bowel Disease Patients.
This review aims to summarise the current literature on employing exhaled breath volatile organic molecules (VOMs) as novel biomarkers for non-invasive testing in inflammatory bowel disease (IBD) patients. Inflammatory bowel disease is a …
Overview of preoperative fasting for general anaesthesia
The primary goal of fasting prior to general anaesthesia is to reduce the risk of pulmonary aspiration, displacement of gastric contents into the lungs. As gastric volume, alongside patient age, current medications …
Prognostic and predictive clinical, pathological, and molecular biomarkers in metastatic colorectal carcinoma – a review
Ongoing research increasingly reveals that metastatic colorectal carcinoma (mCRC) is a highly heterogeneous entity. Despite extension of the median survival of mCRC patients due to advances in therapeutic options available, further improvement …
Molecular Mechanism of Depression: A narrative review of the leading neurobiological theories of Depression
Affective disorders, notably major depression and anxiety, are a significant cause of mortality and morbidity in society today, with the prevalence of depression estimated to be 10-16% in the general …
A review of the resistance mechanisms underlying dabrafenib/trametinib combined therapy in the treatment of BRAF mutant metastatic melanoma
Abstract Background: BRAF mutant metastatic melanoma treatment is most effective when it targets the changes induced within the mitogen-activated protein kinase (MAPK) cas-cade. However, due to the cancer’s heterogeneous nature, …
Sickle Cell Disease and Hydroxyurea Treatment
Abstract Introduction: Sickle cell disease (SCD) is a genetic disorder impacting the patient’s haemoglobin. This condition is accompanied by many dangerous phenotypes, which are the result of pathological haemoglobin polymerisation …